Gene Expression in the Gitr Locus Is Regulated by NF-kB and Foxp3 through an Enhancer
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Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
Glucocorticoid-induced TNFR (Gitr) and Ox40, two members of the TNFR superfamily, play important roles in regulating activities of effector and regulatory T cells (Treg). Their gene expression is induced by T cell activation and further upregulated in Foxp3+ Treg. Although the role of Foxp3 as a transcriptional repressor in Treg is well established, the mechanisms underlying Foxp3-mediated tran...
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